Adapted SynNotch, A New Generation Of Flexible And Controllable CAR T Therapies (Part 3)
This is the final installment in our series on alternate CAR T therapies. Part one describes a version of CAR T which uses a universal adaptor. Part two introduces SNAPtag, an alternative CAR T therapy. Visit the website www.williamhaseltine.com for more on …
How One Man’s Rare Alzheimer’s Mutation Delayed The Onset Of Disease
Neurologists have discovered a genetic mutation that may protect the brain from dementia. Francisco Lopera, a researcher at the University of Antioquia in Colombia, has spent almost forty years studying a family of individuals with a rare form of early-onset Alzheimer’s disease …
SynNotch, A New Generation Of Flexible And Controllable CAR T Therapies (Part 2)
Chimeric Antigen Receptor T cell (CAR T) therapy is a cell-based treatment that has garnered success in treating blood cancers like large B cell lymphoma, leukemia, and multiple myeloma. However, certain limitations prevent the therapy’s adaptation to other diseases. Recent research suggests …
A New Generation Of Flexible And Controllable CAR T Therapies
Chimeric Antigen Receptor T cell (CAR T) therapy is one of the exciting new modalities of cancer treatment. The therapy modifies a patient’s own immune cells to treat specific tumors. This is traditionally accomplished by bioengineering hybrid receptors and attaching them onto …
A New Hope For Osteoarthritis Treatment And Prevention (Part 2)
Osteoarthritis is a common degenerative joint disease that results from aging or injury. Although the swelling, stiffness and pain in the joints can impair daily life or even lead to disability, treatment options are limited. A recent study in Science Advances provides insight …
A New Understanding of Osteoarthritis: Synovial Inflammation Inhibits Cartilage Repair (Part 1)
This is the first of two stories describing recent progress in understanding the cause and potential treatment for osteoarthritis. In part two, we will discuss how this discovery may yield clinical benefits. This story is part of an extensive series on regenerative …
NANOG (Part 2): A Small Protein That Promotes Muscle Growth And Strength
This story on NANOG is part of an extended series on Regenerative Medicine. For other stories on this topic see williamhaseltine.com and search for Regenerative Medicine. My definition of Regenerative Medicine is any medical modality that returns us to normal health when we are …
CAR T Therapy Dramatically Reduces Risk Of Relapse For Multiple Myeloma
More than 35,000 Americans this year will be diagnosed with multiple myeloma, a cancer with an average five year survival rate of 58%. Preliminary study results by Johnson & Johnson and Legend Biotech suggest that their CAR T cell product may benefit …
A Cure For Hepatitis C: Diagnosis And Direct-Acting Antiviral Drugs
This is the fifth installment in my series on progress toward the elimination of Hepatitis C infection and disease. Read more about Hepatitis C in part one, part two , part three, and part four. In previous articles of this series, we’ve discussed several aspects of …
NANOG (Part 1): Its Role In Aging And Cancer
This is the first article in a series on the NANOG protein. Please see my companion series on klotho, another protein that may be involved in aging. You can read more about klotho in parts 1 and 2 of my series. In …
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