In Vivo RNA Injection: A New Treatment for Cancer, Autoimmune Disease and Gene Therapy
Over the last thirty years, protein-based injections and DNA therapeutics accounted for the majority of newly introduced treatments. However, these medicines remain out of reach for many around the world due to high pricing, with some therapies ranging from thousands to several …
A Deeper Look at Anti-PD-1/PD-L1 Checkpoint Inhibitors for Cancer
In a previous story, I described pembrolizumab, a PD-1 targeting checkpoint inhibitor, in some detail. Since its launch, several companies have introduced antibodies targeting the same receptor. This article summarizes some of these recent advances and how they work. Fight Cancer with …
Anti-Cancer Drug Pembrolizumab: Frequently Used Alone or With Other Treatments
A new era of cancer care emerged in the 2010s with the creation of checkpoint inhibitor therapies. These treatments improved the immune system’s innate ability to kill tumors. Pembrolizumab, sold as Keytruda by Merck & Co., was one of the first inhibitors …
IJMS Special Issue: RNA in Biology and Medicine
Dear Colleagues, The advent of messenger RNA vaccines against the severe acute respiratory syndrome coronavirus-2 and certain forms of cancer and studies on noncoding RNAs have ushered in an era of medical uses of RNA. This revolution has been heralded by the …
Ipilimumab, a Pioneer Breakthrough in Cancer Treatment
In 2011, the first in a new generation of anticancer drugs called checkpoint inhibitors was approved. The drug, known as ipilimumab or Yervoy, stood apart from standard cancer treatments. It worked by thwarting a cancer cell’s ability to fend off immune cell …
Can Vitamin D Improve Cancer Immunotherapy?
Whether by rays of sun or through capsules, it’s important for everyone to get their daily dose of Vitamin D. This essential vitamin is known to help the body absorb calcium, the foundation of healthy bones and teeth. New research says this …
Slowing ALS Progression Through Gene Therapy
This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore tissues and organs damaged by disease, injured by trauma, or worn by time to normal …
Fighting Cancer: A Basic Guide to Checkpoint Inhibitors
This article is part of an ongoing series on novel cancer advances, including immunotherapies such as CAR T therapy and checkpoint inhibitors. Future installments will continue to demystify checkpoint inhibitors and explore the latest research expanding the field. In March 2011, a …
Methods To Alter Cellular Gene Expression
This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore tissues and organs damaged by disease, injured by trauma, or worn by time to normal …
A New Weapon Against Cancer: Checkpoint Inhibitors, the Double-Edged Sword
This article joins a growing series on mono cancer treatments, including novel immunotherapies such as CAR T therapy and checkpoint inhibitors. Cutting-edge technologies have transformed the way we treat cancers. While chemotherapy and other traditional treatments directly interfere with cancer cells, immunotherapies …
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