You May Think You Know Your Small Intestine
This story is part of a series exploring human anatomy and physiology complexities. Each story in this collection showcases discoveries reshaping our understanding of the body’s inner workings, potentially changing the way we teach and learn about it in the future. This …
Gene Therapy for a Neurological Disease: Rett Syndrome
Gene therapy may offer hope for people with a rare childhood disease called Rett syndrome. Around one in 10,000 girls are born each year with Rett syndrome, a rare genetic condition that impacts brain development. People with Rett syndrome grow without issue …
Direct Administration of CRISPR-Cas9: Tools for Cell and Gene Therapy
Newly published research offers a novel technique to address a classic problem. Several of the latest cell-based gene and cancer therapies suffer similar drawbacks. The first is that cell manipulation occurs outside the body, a lengthy process that requires extracting, purifying, and …
New Hope For Aggressive Ovarian Cancer
The most common form of ovarian cancer is also the most aggressive. These fast-growing cancer cells initially respond well to standard care—surgery, chemotherapy, monoclonal antibodies and drug inhibitors—but around 70% of patients experience relapse within three years of treatment. A new study …
Artificial Intelligence to Manage the AMD Burden
By 2040, 288 million people worldwide are projected to have age-related macular degeneration (AMD).1 The increasing number of AMD cases calls for more frequent eye examinations. As a result, ophthalmologists will need more time to analyze patient data due to the heavier …
Fight Your Blood Cancer: Early CAR NK Therapy Clinical Results
A robust, ready-made and cell-based cancer therapy inches closer to reality in light of recent progress. Researchers at the MD Anderson Cancer Center released results from their Phase I/II clinical trial on CAR Natural Killer (NK) therapy for blood cancers. The trial demonstrates …
Sniffing Female Tears Reduces Male Aggression
KEY POINTS Tears emit a social chemical signal that is picked up by the olfactory system and lowers aggression in males. Chemical signals in tears strengthen the connection between the aggression and olfactory parts of the brain. This study suggests that tears …
Can CAR T Therapy Be Delivered By Direct Injection?
What if CAR T cells, revolutionary cancer fighters normally manufactured in the lab, could be created inside the patient? This quest to simplify CAR T therapy has brought two biotech companies to a similar answer: viral injections. According to research presented at …
Progress in Treating High Cholesterol: Clinical Trial Interim Results
A new, CRISPR-powered gene therapy seeks to rewrite the rules of cholesterol care. The treatment promises to obliterate ‘bad’ cholesterol with a single infusion, marking a potential paradigm shift in cardiovascular care. A Gene for Bad Cholesterol The balance between “good” cholesterol …
Cre-LoxP: Issues Modulating Genes in the Immune System
Cancer and other diseases could be treated by turning certain genes on and off in the immune system. The method used to activate and inactivate these genes is critical to consider. If the technique does not pinpoint the right cells or lingers …
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