CRISPR Technology To Simplify And Enhance CAR T Cancer Treatment
Here we describe the integration of CRISPR gene-editing technology to improve CAR T therapy design. Other alternative CAR T designs include mRNA vectors to create temporary CAR T cells and the use of antibody switches to control CAR T cell activation. Previous installments discuss the fundamentals …
Researchers Control Cancer Treatment With New Innovation: CAR T Switch(blade)
Here we describe a recent research advancement that fine-tunes CAR T therapy. Previous installments discuss the fundamentals of CAR T and its applications for B cell cancers, multiple myeloma, lupus and the heart. People with treatment-resistant blood cancers turn to CAR T …
Reimagining Alzheimer’s (Part 5): Setback For Potential Alzheimer’s Treatment
This article is the fifth installment in my series on Alzheimer’s disease. Read more about Alzheimer’s disease in part 1, part 2, part 3, and part 4 of the series. In the last installment of my series on Alzheimer’s disease, I discussed a new experimental …
CAR T Therapy: From Cancer To Autoimmune Disease, The Lupus Example
This is the fourth installment in a series on the advances CAR T, a remarkable immunotherapy treatment dubbed a “living drug.” Here we draw attention to promising findings for CAR T lupus treatment. The foundations of CAR T as well as applications …
Salt, Fat And Sugar: How Americans Became Addicted To Eating
“Why can’t I stop myself from overeating?” This is a question that for many cannot be answered simply by a lack of motivation, or genetics. It is the feeling of wanting to eat that last bite of dessert, even though you know …
As Protection From Current Covid-19 Monoclonal Antibody Treatments Fades, The Discovery Of A New Class Of Antibodies Brings Hope
The latest Omicron subvariants are evolving to become more immune evasive, rendering monoclonal antibody treatments such as Evusheld and the forthcoming bebtelovimab ineffective against new strains. With surges predicted in the winter and few mitigation measures left in place, over 17,000 immunocompromised …
Reimagining Alzheimer’s (Part 4): Cautious Optimism For A New Alzheimer’s Disease Treatment
This article is the fourth installment in my series on Alzheimer’s disease. Read more about Alzheimer’s disease in part 1, part 2, and part 3 of the series. The pharmaceutical and biotech companies, Eisai and Biogen recently revealed promising clinical trial results …
Broadly Neutralizing SARS-CoV-2 Antibodies From Immunized Macaque Monkeys
Monoclonal antibodies have been effective in treating in both preventing and treating SARS-CoV-2 infections. However, just as SARS-CoV-2 evolves to evade immune responses by vaccines and natural infection, so too do variants arise that evade neutralization by specific monoclonal antibodies, hence the …
Reimagining Alzheimer’s (Part 3): The APOE Story In Alzheimer’s And Other Diseases
This article is the third installment in my series on Alzheimer’s disease. Read more about Alzheimer’s disease in part 1 and part 2 of the series. Alzheimer’s is a serious disease that affects nearly 6 million people in the United States. Interestingly, some …
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