Viral Awakening: The Hidden Threat of Human Herpes 6 (HHV-6) in CAR T Therapy
Before any treatment, each clinician and patient must determine whether the anticipated benefits outweigh the potential toll caused on the body. Study results published in Nature suggest that latent virus reactivation may be a valid point to consider for CAR T and …
Seeking a Solution: Probiotic-Guided CAR T Cells for Solid Tumors
Beyond yogurt ads and health supplements, probiotics could revitalize cell-based cancer immunotherapies such as CAR T therapy. Surprisingly, a paper published in Science demonstrates show how these live microorganisms can guide supercharged T cells into the solid tumor environment—a feat that current …
UK Approves Groundbreaking CRISPR-based Gene Therapy for Sickle Cell Disease and Thalassemia
This week marks an incredible win for modern medicine. The first CRISPR-based gene therapy has just been approved for clinical use in the United Kingdom. Casegvy (Exa-cel), developed by Vertex and CRISPR Therapeutics, relies on a precise gene-cutting technology first published in …
Opening the Floodgates: The Role of SRC-3 in Regulatory T Cell Suppression
Opening the floodgates of the immune system could help the body fight cancer. As described in a previous installment, researchers at the Baylor College of Medicine successfully eliminated breast and prostate tumors in mice by altering the expression of a specific protein …
How Regulatory T Cells Can Reduce Solid Tumors in Mice
This is the first installment in a group of stories on regulatory T cell function and its potential to treat cancer. This work falls within a greater series on regenerative medicine. In 1999, I defined regenerative medicine as the collection of interventions …
A Different Kind of Cancer Killer: Improving CAR NK Cell Therapy
Recent cancer advance CAR T therapy relies on the killing power of cytotoxic CD8+ T cells to destroy a patient’s cancer, but they are not the only cells that can kill. Natural killer cells also target cancerous cells and could be used …
Wastewater Analysis Update On BA.2.86 In The United States: It’s Here, Be Careful
Fisherman with rod, spinning reel on the river bank. Sunrise. Fishing for pike, perch, carp. Fog against the backdrop of lake. background Misty morning. wild nature. The concept of a rural getaway. – GETTY In a previous article, I described the BA.2.86 …
How mRNA Could Safely Replace Blood Stem Cell Transplantation
This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs that have been damaged by disease, injured by trauma, …
How mRNA Could Cure Sickle Cell Gene Mutations
This story is part of a series on the current progression in Regenerative Medicine. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs that have been damaged by disease, injured by trauma, …
How mRNA Could Reinvent Blood Stem Cell Transplant Preparations
This story is part of a series on the current progression in Regenerative Medicine. This piece discusses advances in stem cell gene therapy. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs …
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