Organoids Point The Way For Liver Regeneration
The liver is the only internal organ that can regenerate itself. Remarkably, even if 70 percent of the liver is removed, its tissue can regrow into a full-sized organ within a matter of months. By unraveling the biological mechanisms behind this unique …
Restoring Cardiac Function With Dual-Chamber Leadless Pacemakers
This story is part of a series on the current progression in Regenerative Medicine. This piece discusses the regeneration of the cardiovascular system. In 1999, I defined regenerative medicine as the collection of interventions that restore to normal function tissues and organs …
Kidney Function Successfully Modeled In Cell Culture
Scientists have made a remarkable breakthrough in kidney research. In a paper published in the journal Biology Communications, a team of researchers at Kyoto University led by Ramin Sadeghian present an innovative approach to building miniature kidney models that closely resemble the …
Treating Troubling Tumors: CAR T Therapy for Aggressive Childhood T Cell Leukemia
In recent years, CAR T therapy has become an established treatment for patients suffering from blood cancers derived from B cells; this includes B cell lymphomas, leukemias and multiple myeloma. However, the therapy has yet to achieve similar success for T cell-derived …
Early Success: mRNA & CAR T Therapy To Treat Rare Autoimmune Disease Myasthenia Gravis
Medical innovation Chimeric Antigen Receptor T cell (CAR T) therapy has attracted attention in recent years for its ability to send difficult-to-treat blood cancers into remission—even curing cancer for a minority. Now, research suggests that the therapy could potentially be adapted to …
New Organ Models Open Up Avenues Of Research For Lung Disease
Lung diseases like emphysema or chronic obstructive pulmonary disease are a leading cause of death worldwide. With the advent of COVID-19, these diseases have only become more prevalent. Despite the severity of lung diseases, there are few available treatments that can alleviate …
The Future Of Cancer Treatment? Treating Multiple Myeloma With MRNA-CAR T Technology
At the frontier of cancer treatment development, there is hope for two modern technologies to combine and achieve unprecedented results: messenger RNA and Chimeric Antigen Receptor T Cell Therapy. Biopharm company Cartesian Therapeutics is determined to use this unique platform to benefit …
To Kill And Kill Again: How Cytotoxic T Cells Attack Target After Target
Cytotoxic T cells, also known as the “killer” T cells, provide the foundation for cell-based CAR T therapy. The therapy borrows and enhances the T cell’s ability to kill multiple targets in rapid succession. This way, the T cell destroys target after …
At Last, People Can Believe Your Pain
When visiting the doctor, one of the first questions patients are asked about their pain is, “How badly does it hurt on a scale from 0-10?”. While these pain ratings are a common method to help physicians diagnose chronic pain syndromes, they …
Adapted SynNotch, A New Generation Of Flexible And Controllable CAR T Therapies (Part 3)
This is the final installment in our series on alternate CAR T therapies. Part one describes a version of CAR T which uses a universal adaptor. Part two introduces SNAPtag, an alternative CAR T therapy. Visit the website www.williamhaseltine.com for more on …
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